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TUDCA if often used to help minimize damage to the liver, whilst Clomid can be taken during and after a cycle, to prevent gynecomastia and help restore testosterone production (2 x 200mg per day)(3). A study looking into the role of cortisol (a hormone produced through the adrenal glands) during male fertility found that this hormone had a strong negative impact on the health of the testicles (4). Cortisol is very difficult to regulate. If it is left uncontrolled, cortisol is associated with a high risk of developing osteoarthritis of the knees, hip and spine or osteoporosis. If it is used in a regulated manner, cortisol levels are not a cause for concern for the body (5). A study by the authors of the Journal of Urology noted that cortisol and testosterone are "triggers for changes in the sperm, endometrium and ovary of healthy, reproductive male subjects exposed to high doses of oral contraceptive pills" (6). If a man is trying to improve fertility due to the effects of excess cortisol, and testosterone, both are vital for fertility. The results of two studies on male fertility found that "testosterone alone is not a risk factor for a negative fertility outcome and has been shown to increase overall fertility after treatment with FSH" (7, 8). As with cortisol use while trying to enhance fertility, it is important to keep in mind that there are always many factors involved, and if any of them interfere with the effectiveness of your fertility treatment it is important that you consult your doctor. References:  Wadden AJ et al. Testosterone treatment is unproven risk factor for the development of reproductive endometrial fibrosis. Urology 2002;59:1857–60.  Gossow L et al. Cortisol treatment for female infertility: a preliminary report. Fertility and Sterility 2002;77:1241–4.  Prakash P et al. Effects of low testosterone level on sperm concentration, sperm morphology and motility in ovulating male rats and on fertility. Reproductive Endocrinology 1984;23:719–23.  Gossow L et al. The effect of high cortisol level on sperm concentration, sperm morphology and sperm motility in ovulating male rats. Reproductive Endocrinology 1984;23:947–54.  De Souza AA et al. Cortisol therapy in male infertility is associated with a prolonged increase in serum oestrogen levels and a decreased sperm concentration. Fertility and Sterility 2000;70:2138–40 Related Article: